abstract：:The immunological environment of leukemic blasts in the bone marrow might play a decisive role in determining an individual's risk for relapse. In order to identify potential predictors of relapse and to elucidate the mechanisms of immune control of leukemic blasts we examined the expression of cytokines, costimulator...

journal_title：European journal of medical research

authors： Stachel D,Albert M,Meilbeck R,Kreutzer B,Haas RJ,Schmid I

更新日期：2006-03-27 00:00:00

abstract：BACKGROUND:In subtotal central retinal artery occlusion (CRAO), distinct retinal edema with acute onset irreversible visual loss is common. - METHODS:Clinical observation, fluorescein angiogram. - PATIENT:A 69-year-old patient presented with acute visual loss of his right eye. Risk factors for CRAO were arterial hype...

journal_title：European journal of medical research

authors： Schmidt D,Böhringer D

更新日期：2006-01-31 00:00:00

abstract：INTRODUCTION:Azathioprine has variable efficacy in inflammatory bowel disease. Previous studies suggested that either neutropenia, an increase in the mean corpuscular volume, the assessment of thiopurine methyl-transferase activity or erythrocyte 6-thioguanine values might predict the treatment response. However, due t...

journal_title：European journal of medical research

authors： Glas J,Török HP,Daczo J,Tonenchi L,Folwaczny M,Folwaczny C

更新日期：2005-12-07 00:00:00

abstract：BACKGROUND:Data on lung volumes and changes in flow-volume spirometry at high altitude are few and do not provide comprehensive assessment of the occurring changes. This study characterizes alterations of the forced expiratory flow-volume curve (FEFV-curve) and lung volumes at increasing altitude. METHODS:FEFV-curve a...

journal_title：European journal of medical research

authors： Fischer R,Lang SM,Bergner A,Huber RM

更新日期：2005-11-16 00:00:00

abstract：OBJECTIVES:At workplaces, organic solvents are often used as mixtures. Nevertheless, there is limited knowledge of their acute effects on human central nervous system. Here we report the effects of a toluene-acetone mixture. METHODS:In a parallel design, subgroups of 12 healthy men each were exposed to a mixture conta...

journal_title：European journal of medical research

authors： Muttray A,Martus P,Schachtrup S,Müller E,Mayer-Popken O,Konietzko J

更新日期：2005-09-12 00:00:00

abstract：BACKGROUND:Congenital fibrosis of the extraocular muscles type 1 (CFEOM1) is a congenital, non-progressive autosomal-dominant disorder with bilateral oculomotor nerve palsy due to mutations in the kinesin motor protein gene KIF21A. - RESULTS:We present a 60-year old patient with CFEOM1 due to the common C2860T mutatio...

journal_title：European journal of medical research

authors： Hanisch F,Bau V,Zierz S

更新日期：2005-08-17 00:00:00

abstract：BACKGROUND:The more frequent use of endoscopic ultrasonography (EUS) leads to an increased number of diagnosed gastric submucosal tumors (G-SMT). Since until now rather little therapeutical success in respect of these tumors has been achieved, we evaluated our concept of watchful waiting and selective treatment of pati...

journal_title：European journal of medical research

authors： Sato T,Peiper M,Fritscher-Ravens A,Gocht A,Soehendra N,Knoefel WT

更新日期：2005-07-29 00:00:00

abstract：:Basal cell carcinoma (BCC) is the most common skin cancer, occurring more frequently than malignancies of any other tissue or organ, either individually or in total. Medical treatment modalities of BCC offer cost reduction and clinical advantages in selected cases. Neomycin has been reported to have an important role ...

journal_title：European journal of medical research

authors： Cuevas P,Arrazola JM

更新日期：2005-05-20 00:00:00

abstract：:Gadolinium chelates are widely used in magnetic resonance imaging as contrast medium in patients with nephropathy. However, only few studies have investigated the effect of gadolinium on serum creatinine concentration and estimated GFR as surrogate markers of renal function. This study was performed to evaluate the ef...

journal_title：European journal of medical research

authors： Hoffmann U,Fischereder M,Reil A,Fischer M,Link J,Krämer BK

更新日期：2005-04-20 00:00:00

abstract：:The authors report a large duodenal somatostatinoma, a very rare tumor entity. A 8.5 cm globular mass in the area of the unicate process of the pancreas was detected in a 45 year old caucasian female by computerized tomography. The patient had only mild complaints. Initial treatment consisted of right pancreatectomy w...

journal_title：European journal of medical research

authors： Bastian PJ,Eidt S,Koslowsky TC,Wulke AP,Siedek M

更新日期：2005-03-29 00:00:00

abstract：BACKGROUND:Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant tumor syndrome predisposing to predominantly colorectal and endometrial cancer. In 90% of the cases, molecular analyses reveal microsatellite instabilities due to germline mutations in DNA mismatch repair (MMR) genes, mainly MLH1, MS...

journal_title：European journal of medical research

authors： Schiemann U,Müller-Koch Y,Gross M,Glas J,Baretton G,Muders M,Mussack T,Holinski-Feder E

更新日期：2005-01-28 00:00:00

abstract：BACKGROUND:Reporting of all serious adverse events (SAEs) is a requirement for regulatory approval of a drug. Can equally rigorous reporting standards be expected in studies of non-drug treatments and how can underreporting, if any, be detected and proven? Using data from our large-scale prospective cohort study of acu...

journal_title：European journal of medical research

authors： Endres HG,Molsberger A,Lungenhausen M,Trampisch HJ

更新日期：2004-12-22 00:00:00

abstract：:Previous studies on Langerhans'-cell histiocytosis (LCH) were mostly retrospective and patients had been recruited over a long time period. The aim of the present study was to establish data on the clinical presentation, diagnosis and treatment of currently affected patients. Data on the clinical history, diagnostic w...

journal_title：European journal of medical research

authors： Götz G,Fichter J

更新日期：2004-11-29 00:00:00

abstract：AIM:Antiseptics are commonly used in clinical practice to disinfect tissue and to avoid infections. However, topical antiseptics are assumed to have an influence on skin microcirculation, per se. Thus, the aim of the study was to analyse the influence of topically applied antiseptics on the microcirculation of intact s...

journal_title：European journal of medical research

authors： Langer S,Sedigh Salakdeh M,Goertz O,Steinau HU,Steinstraesser L,Homann HH

更新日期：2004-09-29 00:00:00

abstract：OBJECTIVE:Most industrialized countries experienced a change in dietary habits within the last 10 years. Growing obesity may result in an increased incidence of metabolic diseases as well as in a higher caries frequency. METHODS:In an interdisciplinary study, 842 elementary school children (414 girls and 428 boys, age...

journal_title：European journal of medical research

authors： Willershausen B,Haas G,Krummenauer F,Hohenfellner K

更新日期：2004-08-31 00:00:00

abstract：:In Germany during the past years about 200-250 HIV infected pregnant women delivered a baby per year, a number that is currently increasing. To determine the HIV-status early in pregnancy voluntary HIV-testing of all pregnant women is recommended in Germany and Austria as part of prenatal care. In those cases, where H...

journal_title：European journal of medical research

authors： Buchholz B,Grubert T,Marcus U,Beichert M,Gingelmaier A,Brockmeyer NH,German AIDS-society (DAIG).,Austrian AIDS-society (OEAG).,HIV-AIDS competence network.,Robert-Koch Institute Berlin (RKI).,German Association of Physicians Speciali

更新日期：2004-06-30 00:00:00

abstract：:Acute liver failure represents one of the most challenging conditions in intensive care treatment. In most cases there is no causal medical therapy available for survive making the intensive care treatment as the most important management tool, as bridge to transplant or still the recovery of the liver! These patients...

journal_title：European journal of medical research

authors： Saner FH,Kavuk I,Lang H,Stavrou G,Paul A,Doemland M,Malagó M,Broelsch CE

更新日期：2004-05-28 00:00:00

abstract：:So far, neither treatment with standard unfractionated heparin (UFH) nor with low-molecular-weight heparin (LMWH) has been shown to reduce mortality or to improve neurological outcome in patients with acute ischemic stroke. Although a reduction of early recurrent stroke has been demonstrated for the use of subcutaneou...

journal_title：European journal of medical research

authors： Busch M,Masuhr F

更新日期：2004-04-30 00:00:00

abstract：:In the absence of thromboprophylaxis, venous thromboembolism (VTE) affects about 50 to 80% of the patients after total hip replacement (THR), total knee replacement (TKR), or hip fracture surgery. Since stratification of patients in those who will become symptomatic and those who will not, is not possible, primary hig...

journal_title：European journal of medical research

authors： Eichinger S,Kyrle PA

更新日期：2004-03-30 00:00:00

abstract：OBJECTIVE:Due to the side effects of antiretroviral therapy and long term survival there is an increasing concern of an elevated rate of cardiovascular diseases in HIV-infected patients. The present study analysed the cardiovascular risk profile and the probability of cardiovascular events in HIV-infected patients, due...

journal_title：European journal of medical research

authors： Neumann T,Woiwod T,Neumann A,Ross B,Von Birgelen C,Volbracht L,Brockmeyer NH,Gerken G,Erbel R

更新日期：2004-02-27 00:00:00

abstract：AIM:The aim of the in vitro study was to examine the effect of estradiol and progesterone on the proliferation rate of human gingival fibroblasts (HGF) derived from a healthy and a diabetic (type II) individual. METHODS:In the first experiment, cells in the logarithmic proliferative phase were incubated with estradiol...

journal_title：European journal of medical research

authors： Christoffers AB,Kreisler M,Willershausen B

更新日期：2003-12-09 00:00:00

abstract：:Polyadenosylation of nuclear enzymes is well known to regulate the cellular repair capacity after DNA damage. PARP mediates the transfer of poly-ADP-ribose moieties on itself and other nuclear proteins by the breakdown of NAD+. The present study investigated how modulation of PARP activity interferes with cell death i...

journal_title：European journal of medical research

authors： Pogrebniak A,Schemainda I,Pelka-Fleischer R,Nüssler V,Hasmann M

更新日期：2003-10-22 00:00:00

abstract：:More than one quarter of total daily calories are normally provided by fatty acids which contain at least one double bond. The usual configuration of these double bonds is the cis configuration. Trans fatty acids (TFA) are formed in technological and microbiological processes by isomerization of cis double bonds to tr...

journal_title：European journal of medical research

authors： Steinhart H,Rickert R,Winkler K

更新日期：2003-08-20 00:00:00

abstract：:Triple A (four A; Allgrove syndrome) syndrome is a an autosomal recessive disorder characterized by alacrimia, achalasia, adrenocortical insufficiency, and various neurological abnormalities. We report a case of triple A syndrome in a 14-year-old female patient together with oral manifestations. The importance of this...

journal_title：European journal of medical research

authors： Vucicevic-Boras V,Juras D,Gruden-Pokupec JS,Vidovic A

更新日期：2003-07-31 00:00:00

abstract：:While for many allergens a dose-response relationship has clearly been established the association between early childhood exposure to cat allergens and risk of sensitisation is still controversial and even inverse relations have been described. At the same time, a negative association between Toxoplasma gondii (T. go...

journal_title：European journal of medical research

authors： Radon K,Dressel H,Windstetter D,Reichert J,Schmid M,Nowak D

更新日期：2003-04-30 00:00:00

abstract：:The 825T-allele of the C825T polymorphism in GNB3, the gene for the G protein beta3 subunit, has been reported to be associated with essential hypertension and obesity. Expression of Gbeta3s, the gene product of GNB3 associated with the GNB3 825T-allele, causes increased signal transduction which may contribute to pat...

journal_title：European journal of medical research

authors： Saller B,Nemesszeghy P,Mann K,Siffert W,Rosskopf D

更新日期：2003-03-27 00:00:00

abstract：:HIV-1 protease inhibitors have contributed significantly to the reduction in morbidity and mortality associated with HIV-1 disease. Some of their clinical benefit may be attributed to inhibition of non-viral pathogen proteases and mammalian proteases involved in apoptosis. Our objective was to investigate the effect o...

journal_title：European journal of medical research

authors： Wolf T,Findhammer S,Nolte B,Helm EB,Brodt HR

更新日期：2003-01-28 00:00:00

abstract：OBJECTIVE:Evaluating the effects of prophylactic administration of IgM-enriched immunoglobulins (IVIG) on immunological- and clinical parameters in cardiac surgical patients. PATIENTS AND METHODS:41 patients were randomized to receive either an IgM-enriched immunoglobulin (Pentaglobin(R)) preparation (1,300 ml immunog...

journal_title：European journal of medical research

authors： Friedrich I,Silber RE,Baumann B,Fischer C,Holzheimer RG

更新日期：2002-12-17 00:00:00

abstract：:Under antidepressive treatment with amitryptiline (100 mg/d) a 71-year old woman developed delirious symptoms, hyponatremia and a grand mal seizure followed by cardiovascular arrest. A few month later she ingested 48 mg reboxetine with suicidal intent. Overdosing of reboxetine, a selective noradrenaline re-uptake inhi...

journal_title：European journal of medical research

authors： Agelink MW,Ullrich H,Passenberg P,Sayar K,Brockmeyer NH

更新日期：2002-09-30 00:00:00

abstract：OBJECTIVE:Efavirenz (EFV) plasma levels have been discussed as a predictor of treatment failure in HIV infected patients. The aim of this prospective, open-labeled, case-control study was to evaluate pretreated patients in regards to efavirenz plasma levels and efficacy of therapy. METHODS:Blood samples were obtained ...

journal_title：European journal of medical research

authors： Langmann P,Weissbrich B,Desch S,Väth T,Schirmer D,Zilly M,Klinker H

更新日期：2002-07-24 00:00:00

abstract：BACKGROUND:Children with persistent mild to moderate bronchial asthma require anti-inflammatory therapy. According to current treatment guidelines both sodium cromoglycate (SCG) and inhaled corticosteroids can be used. If children remain symptomatic despite regular SCG therapy, corticosteroids are the next therapeutic ...

journal_title：European journal of medical research

authors： von Berg A,Gappa M,Steinkamp G,Flit-DNCG Study Group.

更新日期：2002-06-28 00:00:00

abstract：:Invasive aspergillosis and disseminated candidiasis are the two major manifestations of opportunistic invasive mycoses. Their incidence has risen considerably during the past decades, due to more intensive anticancer chemotherapy, organ transplantations, intensive care, and aggressive surgical interventions. Especiall...

journal_title：European journal of medical research

authors： Kullberg BJ,Oude Lashof AM

更新日期：2002-05-31 00:00:00

abstract：BACKGROUND:Several studies have been performed in tumour patients to analyse the immunological response to mistletoe extracts. Considering the fact that these extracts are given subcutaneously in most instances, the kind of application resembles a typical immunization schedule. We therefore wanted to see how those extr...

journal_title：European journal of medical research

authors： Klein R,Classen K,Berg PA,Lüdtke R,Werner M,Huber R

更新日期：2002-04-30 00:00:00

abstract：INTRODUCTION:Recombinant human growth hormone (r-hGH) has demonstrated efficacy in treating HIV-associated wasting (HAW), however, HAW has become less prominent since the introduction of highly active antiretroviral therapy (HAART). Recent studies suggest that patients receiving HAART may still experience HAW. We inves...

journal_title：European journal of medical research

authors： Jäger H,Knechten H,Moll A,Weitner L,Fischer H,Schmitt-Rau K

更新日期：2002-03-28 00:00:00

abstract：AIMS:This study assessed the prevalence of substance use among Iranian patients with cardiovascular disease who were admitted in different cardiac wards at Shiraz general hospitals. DESIGN:Cross-sectional survey using structured interview and also using DSM-IV criteria for substance dependency. SETTING:General hospit...

journal_title：European journal of medical research

authors： Ahmadi J,Benrazavi L

更新日期：2002-02-21 00:00:00

abstract：:Though AIDS-related morbidity and mortality are generally decreasing as a result of highly active antiretroviral therapy (HAART) and prevention of opportunistic infections, dual infection with HCV and HIV leads to an acceleration in the natural course of chronic hepatitis C (cHC) and worsening of associated liver dise...

journal_title：European journal of medical research

authors： Tossing G

更新日期：2002-01-29 00:00:00

abstract：BACKGROUND:The Orthogonal Polarization Spectral (OPS) imaging technique has been introduced for in vivo assessment of microcirculation in humans. Unclear remains, whether the new technique would allow for accurate investigations of the colon microcirculation with respect to the unique conditions of the microvasculature...

journal_title：European journal of medical research

authors： Biberthaler P,Langer S,Luchting B,Khandoga A,Messmer K

更新日期：2001-12-17 00:00:00

abstract：:We report the first case of a well defined extrinsic allergic alveolitis as a complication of sulfasalazine therapy in a patient treated for psoriatic arthritis. CT of the chest showed small nodular densities over both lungs, BAL demonstrated a highly active lymphocytic alveolitis and transbronchial biopsies revealed ...

journal_title：European journal of medical research

authors： Woltsche M,Woltsche-Kahr I,Roeger GM,Aberer W,Popper H

更新日期：2001-11-20 00:00:00

abstract：BACKGROUND:A great variety of dental materials are now available for use in restorative treatments. Much attention has been devoted to physical and chemical properties, but the biological effects of these materials have been less frequently studied. AIM:The aim of this study is to test the influence of resin based res...

journal_title：European journal of medical research

authors： Willershausen B,Köttgen C,Ernst CP

更新日期：2001-10-29 00:00:00

abstract：:Retinyl palmitate and its metabolites retinol and retinoic acid control growth and epithelial differentiation. Systemic or local vitamin A deficiency induced by malnutrition, continuous chemical irritation or locally induced by inflammation causes squamous metaplastic changes in the epithelium of mucous membranes. We ...

journal_title：European journal of medical research

authors： Biesalski HK,Sobeck U,Weiser H

更新日期：2001-09-28 00:00:00